http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2027256-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2d5b7694963e2dddece400ef00db4b3a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0331 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0271 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 |
| filingDate | 2007-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8301b960bb866bef36aaa19315792c9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecdc1e4343f9d8f5f89e52ea4adb262c |
| publicationDate | 2009-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2027256-A2 |
| titleOfInvention | Animal models of tumour metastasis and toxicity |
| abstract | The present invention relates to a methodology designed to convert an animal into appropriate recipients of tumour cells derived from a different species. Animals thereof are immuno-incompetent animals that are doubly grafted with orthotopic tissues: One grafted tissue (i.e. breast) is from an organ of the same class as the tumour of origin (graft A). The second grafted tissue (i.e. bone) is from a organ of the same class as a target organ for metastasis (graft B). These dual grafted animals can be used to model human diseases. A preferred model will be one in which human tumour cells are orthotopically seeded in graft A in order to analyze the occurrence of metastasis in graft B. Also in this invention are included methods and compositions to create a multiorgan human environment in mice. This will be achieved by grafting human stem cells (mesenchymal, embryonic or others) into mice. Mice in this invention can be conveniently injured to enhance tissue specific engraftment. As in double grafted mice, such chimeric mice can be used to grow human tumours and to study the occurrence of metastasis. |
| priorityDate | 2006-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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