| abstract |
RNA interference is provided for inhibition of tumor necrosis factor alpha (TNFalpha) by silencing TNFalpha cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFalpha converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFalpha targets, in particular, is useful for treating patients having a TNFalpha-related condition or at risk of developing a TNFalpha-related condition such as the ocular conditions dry eye, allergic conjunctivitis, or ocular inflammation, or such as dermatitis, rhinitis, or asthma, for example. |