http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2010644-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8903a516e8bc59fe6f2f31812f04032 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-00 |
| filingDate | 2008-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42c4fda24ec61bea03ca06a0c8078e43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff764db4d8b43fecfde49b55194e5ea6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8de74a22d1c46070a2403e4a3be1773c |
| publicationDate | 2009-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2010644-A1 |
| titleOfInvention | New micro-organisms for the production of acetol obtained by a combination of evolution and rational design. |
| abstract | The present invention concerns a new method combining evolution and rational design for the preparation of a strain of micro-organism for the production of acetol from a simple carbon source. The said method comprises: - growing an initial strain under selection pressure in an appropriate growth medium, said initial bacterial strain comprising an attenuation of the expression of the tpiA gene and an attenuation the expression of at least one gene involved in the conversion of methylglyoxal to lactate, in order to promote evolution in said initial strain, - then selecting and isolating the evolved strain having an increased acetol or 1,2- propanediol production rate, - then reconstructing a functional tpiA gene in the evolved strain. The present invention also concerns the evolved strain such as obtained, that may be furthermore genetically modified in order to optimize the conversion of a simple carbon source into acetol without by-products and with the best possible yield. |
| priorityDate | 2007-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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