| abstract |
Use of a compound of formula (I): [Chemical formula should be inserted here. Please see paper copy] wherein: R1 is phenyl optionally substituted by halogen, cyano, C1-4#191 alkyl or C1-4#191 haloalkyl; R2 is hydrogen, C1-6#191 alkyl or C3-6#191 cycloalkyl; and R3 is a group having an NH or OH that has a calculated or measured pKa of 1.0 to 8.0; or a pharmaceutically acceptable salt thereof; in the manufacture of a medicament for use in the treatment of osteoarthritis or osteoarthrosis. The invention also concerns the benzenesulfonate salt of N-{3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]-2-hydroxypropyl}-2,3-dihydro-2-oxo-4-(trifluoromethyl)-5-thiazolecarboxamide, a process for making it, and its use in therapy (for example in treating CCR3 mediated disease states). |