| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 |
| filingDate |
2007-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39a0cd34c8e877db1898a00335ef0f2f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a134dc125254d006b5deddf983baa385
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92e4a6694067f1ee9ca3299699eaa4b9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_258ed0764c7a5a37b0f27c8d6707f2cb |
| publicationDate |
2009-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2007731-B1 |
| titleOfInvention |
Process for the preparation of caprolactam cgrp antagonist intermediate |
| abstract |
An efficient syntheses for the preparation of (3R,6S)-3-amino-6-(2,3- difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one. The process uses a crystallization driven asymmetric transformation to set the amine stereocenter followed by a cis-selective hydrogenation and epimerization to set the benzylic stereocenter and trans geometry. |
| priorityDate |
2006-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |