http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2004838-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d9e9bb060c56c2598e99bc95c6391ca1 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P33-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P33-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P33-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P33-16 |
| filingDate | 2007-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be74da1233a1b1ac6c60c798bb67251a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_765608676728d0603c277ed3161d57b0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79c618df31257391858e0f47418e67bc |
| publicationDate | 2012-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2004838-B1 |
| titleOfInvention | Process for the preparation of steroid derivatives by reduction of oxosteroid compounds or by oxidation of hydroxysteroid compounds using a hydroxysteroid dehydrogenase |
| abstract | A process for the enantioselective enzymatic reduction of compounds which have a steroid structure (ABCD), including one or more heteroatoms, one or more double bonds and/or an aromatic in the ring structure and which have at least one oxo group at position 3, 7, 11, 12 or 17 of the steroid ring system or in α-position at any carbon radical on the steroid skeleton (= oxosteroid compound/hydroxysteroid compound), where the oxosteroid compound is reduced with a hydroxysteroid dehydrogenase in the presence of a cofactor NADH or NADPH is characterized in that a) the oxosteroid compound is present in the reaction mixture in a concentration of >50 g/l, b) the oxidized cofactor NAD or NADP which is formed by the hydroxysteroid dehydrogenase is regenerated continuously by oxidation of a secondary alcohol of the general formula RxRyCHOH where Rx, Ry independently of one another represent hydrogen, branched or unbranched Cl-C8-alkyl and Ctotal ≥3, or by oxidation of a C4-C6-cycloalkanol, and c) an additional oxidoreductase/alcohol dehydrogenase is employed for oxidizing the secondary alcohol of the general formula RXRYCHOH or of the cycloalkanol. |
| priorityDate | 2006-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 483.