http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1987813-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_666d69a0b9503881fd0bacaeb7b4e489 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1277 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 |
| filingDate | 2007-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6829dcf6bf7621412f59b77ba9c96bff |
| publicationDate | 2008-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1987813-A1 |
| titleOfInvention | Injectable pharmaceutical formulation of taxoids in stable liposomes |
| abstract | The present invention concerns an injectable pharmaceutical composition of taxoids in stable liposomes. The formulation comprises the taxoid, a phospholipid, a viscosity improver and optionally a solvent for the phospholipid. n The formulation is prepared according to the following steps: na) Solubilization of the phospholipid in a solvent, preferably ethanol; nb) Addition of a Taxoid and its solubilization under stirring; nc) Addition of a viscosity improver, preferably glycerol, under stirring; nd) The solution is sterilized by filtration with a PTFE hydrophobic membrane with a size of 0.22 micron, in sterile room (Class A); ne) In another vessel, sterile water for injection is prepared by filtration of water with a PTFE hydrophilic membrane with a size of 0.22 micron, in sterile room (Class A); nf) A minimal amount of water obtained in e) is added to the ethanol solution of d) to achieve the formation of liposomes. The suspension is left under vigorous stirring for at least 20'. The temperature is preferably comprised between 20 and 25°C; ng) The suspension is brought to the final volume by addition of sterile water obtained in e) at a pH comprised between 5.5 and 7.5; nh) The liposome's suspension is bottled sterilely. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012141565-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8778367-B2 |
| priorityDate | 2007-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.