http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1978014-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_299cff96bb72ae26b6cfe2d849f81bc9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 |
| filingDate | 2007-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b5e5fff98cbdd184bfd4004827e8f6e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87ea5dec9072a362d5498593ad25229b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1525caf3710fc4279b5b1b8263a3cfd3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_571ff815f016fceee2ae2df713384fb4 |
| publicationDate | 2008-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1978014-A1 |
| titleOfInvention | Process for the preparation of entacapone and intermediates thereof |
| abstract | New preparation process for the preparation of entacapone which comprises converting the 3,4-dimethoxy-5-nitrobenzoic acid into an activated derivative which is reacted with 2-cyano-N,N-diethylacetamide in the presence of a base to give 2-cyano-3-(3,4-dimethoxy-5-nitrophenyl)- N , N -diethyl-3-hydroxyacrylamide; reacting the resulting compound with MHB(OCOR) 3 where R is (C 1 -C 4 )-alkyl, phenyl, or CF 3 ; and M is a sodium, potassium or ((C 1 -C 4 )-alkyl) 4 N, in the presence of an appropriate solvent to give E -2-cyano-3-3,4-dimethoxy-5-nitrophenyl)- N,N -diethylacrylamide; and finally submitting the compound obtained to a demethylation reaction to yield entacapone. Both 2-cyano-3-(3,4-dimethoxy-5-nitrophenyl)- N,N -diethyl-3-hydroxyacrylamide and E -2-cyano-3-3,4-dimethoxy-5-nitrophenyl)- N,N -diethylacrylamide are new. Entacapone has industrial applicability as antiparkinson's agent. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105061259-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018036498-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3885337-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2251323-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016206573-A1 |
| priorityDate | 2007-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 157.