http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1968943-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bfb47c84e5744717235d206b662b2bbc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-18 |
| filingDate | 2006-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5d13dd698b139b2ebf974015378c223 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3a9b58932cc0c11a084ec09835c7aa6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a65880db3c7dc1efdd951fef3860f0a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c5c2ad869f6324c1f17f1ed4bd242ff |
| publicationDate | 2008-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1968943-A1 |
| titleOfInvention | An improved process for the preparation of montelukast and its pharmaceutically acceptable salts |
| abstract | An improved process for the preparation of Msntelukast and its pharmaceutically acceptable salts comprises of reacting (S) Benzenepropanol a -[3-[2-(7-chloro2-quinolinyl) ethenyl]phenyl]-2-(l-hydroxy-1-methyl ethyl)-a-methane sulfonate compound of formula (II) with l-(mercapto methyl) cyclo propane acetic acid or its ester or nitrile in presence of alkali or alkaline carbonates and/or alkali or alkaline earth metal alkoxide in a suitable polar aprotic solvent with or without combination of C<SUB>1</SUB>-C<SUB>4</SUB> alcoholic solvents and then treating with organic amine in a suitable ester and/or acetone and/or aliphatic or aromatic hydrocarbon solvents, and converting the corresponding amine salt compound of montelukast into its sodium salt compound of formula (I) using sodium ion source in methanol, without converting into montelukast free acid. |
| priorityDate | 2005-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 223.