Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6889 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6875 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6867 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6855 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-14 |
filingDate |
2006-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd4cd83f6ae009e2c5aaf891baff00d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1f4f82a527638d5a7240acadd68b71c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c298fbbe03aa3b21db3b19a00c2ae982 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5775f99a61ef698b4c9a2302198c257 |
publicationDate |
2008-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-1954317-A2 |
titleOfInvention |
Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use |
abstract |
The invention relates to bis 1, 8 naphthalimide compounds including antibody drag conjugate (ADC) compounds represented by Formula (I) : where one or more 1, 8 bis-naphthalimide drug moieties (D) having Formulas (IIa) and (IIb) are covalently linked, through the wavy line, by a linker (L) to an antibody (Ab). The invention also relates to heterocyclic-substituted 1, 8 bis-naphthalimide compounds having Formula (XV). The invention also relates to pharmaceutical compositions comprising an effective amount of a Formula (I) ADC or Formula (XV) heterocyclic-substituted 1, 8 bis-naphthalimide compound for treatment of hyperproliferative disorders and other disorders. The invention also relates to methods for killing or inhibiting the proliferation of tumor cells or cancer cells including administering to a patient an effective amount of a Formula (I) ADC or Formula (XV) compound. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101364941-B |
priorityDate |
2005-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |