| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_57f3e2af72b2933c004ed61dfccaaee1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9121
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-715
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-912
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N1-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y30-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate |
2006-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4c3aa4c5db638973e2f8edf71c9b222
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9592821a50a78ccfb73ebbc77599fff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_322953dcd2d19caba4563fd63b0917a5 |
| publicationDate |
2008-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1946112-A2 |
| titleOfInvention |
Predictive methods for cancer chemotherapy |
| abstract |
This invention provides methods and reagents for determining or predicting responses to cancer therapy, as well as dual therapy treatments. The methods involve identifying mammalian tumors that can be treated with dual mTOR pathway inhibitor and EGF pathway inhibitor therapy, comprising the step of assaying a sample from the tumor to detect expression and/or phosphorylation of polypeptides of the EGF pathway and of the mTOR pathway. EGF pathway polypeptides may include ERK and MEK, while mTOR pathway polypeptides may include mTOR and/or HIF-I alpha . |
| priorityDate |
2005-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |