http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1939182-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_89569608abc52a4a8dbe3ac3caff6835 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 |
| filingDate | 2006-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1939182-A1 |
| titleOfInvention | Process for the preparation of (R or S)-2-Alkyl-3-heterocyclyl-1-propanols |
| abstract | Compounds of the formula 1, wherein R ' 1 , R' 2 , R ' 3 and Het have the meanings given in the description are obtainable in high yields by a stereoselective addition of R' 3 -substituierten propionic acid to R ' 1 - and R' 2 -substituierte unsaturated, bicyclic Heterocyclylaldehyde the formula R-CHO to corresponding 3-R-3-hydroxy-2-R ' 3 -propionsäureestern. Conversion of the OH group into a leaving group, followed by regioselective elimination to 3-R-2-R ' 3 -propenoic acid esters, followed by 1) saponification to the corresponding 3-R-2-R ' 3 -propenoic acids, their enantioselective hydrogenation to corresponding chiral 3-R-2-R' 3 -propenoic acids and their reduction, or 2) the saponification to the corresponding 3-R-2-R ' 3 -propenoic acids, their reduction to corresponding 3-R-2-R' 3 -allyl alcohols and their enantioselective hydrogenation, or 3) the reduction to corresponding 3-R-2-R ' 3 -allyl alcohols and their enantioselective hydrogenation, wherein R is for and the enantioselective hydrogenations are carried out with metal complexes having as ligands ferrocene-1,1'-diphosphines which have a ferrocene-substituted, secondary phosphine group in the 1-position and a secondary phosphine group in the 1 'position. |
| priorityDate | 2006-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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