http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1933830-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1cfe242f0f35430601ac180fd3792aed |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-397 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-397 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P23-00 |
| filingDate | 2006-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a664d4ab985c69517414f9946475518d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6140820be51d350bddbba1d52207de13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aab614f077cab984b3fc39b3e47416c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a1c2bebcbc0cca87221016bc09fa1f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a010880b7b9bfcfe665957e51fb3636d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5c6fcc750897f4b95fdb48fedae8ea6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e006429d6f1e4843807e72445d78051c |
| publicationDate | 2008-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1933830-A1 |
| titleOfInvention | Antagonists of sns sodium channels |
| abstract | Compounds of the formula (I), and pharmaceutically acceptable salts thereof, are found to be antagonists of SNS sodium channels. They are therefore useful as analgesic and neuroprotective agents, formula (I): R1 represents: (a) -L-A or -L' -A' wherein L represents a bond or a C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl moiety, A represents a phenyl, 5- to 10-membered heteroaryl, C3-C6 carbocyclyl or 5- to 10-membered heterocyclyl group, L' represents a C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl moiety, and A' represents -Het-A or -X-A wherein Het represents -O-, -S- or -NR'-, and X represents -CO-, -SO-, -SO2-, -CO-O-, -CO-S-, -CONR'-, -O-CO-, -S-CO- or -NR'-CO-, wherein R' represents hydrogen or C1-C6 alkyl; (b) -L-CR(A)(A') or -L-CR(A)(L-A) wherein R is hydrogen or C11-C4 alkyl, A' is as defined above, each L is the same or different and is as defined above and each A' is the same or different and is as defined above; (c) -L-A-A' or -L-A-L-A wherein A' and L are as defined above and each A is the same or different and is as defined above; or (d) -A-Z-A wherein Z is -Het-L'-, -X-L'-, -L'-Het- or -L'-X-, wherein Het, L' and X are as defined above and each A is the same or different and is as defined above; J represents -NR5-, -O- or a direct bond; R5 represents hydrogen, C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl; R4 is represents hydrogen, C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl; and either R2 represents -L-A, -L-A’, -L-A-A’, -L-A-L-A, -L-CR(A)(L-A), -L- CR(A)(A’) or -L-CR(A)(L') wherein L' is -Het-L', -X-L', -CONH2 or -CO2H, and wherein A', Het, X and R are as defined above, each L is the same or different and is as defined above, each A is the same or different and is as defined above and R3 represents hydrogen, C1-C6 alkyl C2-C6 alkynyl or (CO)-L', wherein L is as defined above or R2 and R3 form, together with the nitrogen to which they are attached, a 5-to 10-membered heteroaryl or 5-to 10-membered heterocyclyl ring. |
| priorityDate | 2005-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 788.