| abstract |
The invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein Y is -NRaRb, -NRcC=ONRaRb' -NRcC=SNRaRb, -NRcC=NRdNaRb, heterocycle, - C=ONRaRb, heterocycle, or aryl; n is O to 8; m is 0, or 1; r is 0 to 3; t is O to 3; X is O or N; Z is CH2, C=O, C=S or a single bond; Z1 is CO-R2, CS-R2, (CH2)t-R2 or the side-chain of a naturally occuring amino acid;, Z2 is CO-R2, CS-R2 or (CH2)t-R3 or the side-chain of a naturally occuring amino acid; Z3 is CO-R2, CS-R2 or (CH2)t-R4 or the side-chain of a naturally occuring amino acid; Z4 is H, alkyl, alkoxy, or cycloalkyl; R1, R2, R3, and R4 are independently from each other H, OH, SH, NH2, CN, NO2, alkyl, cycloalkyl, heterocycloalkyl, haloalkyl, alkylthio, haloalkyloxy, hydroxyalkyl, hydroxyalkylarnino, alkylamino, alkylaryl, alkylsulfinyl, alkylsulfonyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, alkoxyalkyl, alkoxy, aryloxy, heteroaryl, aryl, or halogen. |