| abstract |
Disclosed are a bioactive protein-calcium phosphate ceramic composite for surface modification of a substrate for use as a substitute in the treatment of musculoskeletal disorders, and a preparation method thereof. The bioactive protein-calcium phosphate ceramic composite is prepared by mixing an aqueous solution of calcium phosphate and a protein, and impregnating the calcium phosphate and the protein in the resulting aqueous solution to co-precipitate them on a substrate, such as metals, ceramics and polymers, wherein the substrate is patterned, and different proteins are impregnated in at least two regions of the patterned regions. |