| abstract |
An active ingredient is a compound represented by the general formula [I]:n n[wherein R 1 and R 2 represent a lower alkyl group, a C 3-6 cycloalkyl group or the like, X 1 and X 2 represent methine, an Ar-Y 1 -Y 2 -Y 3 -substituted methine or the like, however either of them is an Ar-Y 1 -Y 2 -Y 3 -substituted methine, X 3 to X 8 represent methine, -N- or the like, Y 1 and Y 3 represent a single bond, -O- or the like, Y 2 represent a single bond, a lower alkylene group or the like, W represent -(O)-(CH 2 )n-(O)- or the like, n represents an integer of 1 to 4, L and Z 2 represent a single bond or a methylene group, Z 1 represents a single bond, a C 1-4 alkylene group or the like, and Ar represents an aromatic carbocyclic group or the like]. The compound acts as a melanin-concentrating hormone receptor antagonist and useful as a therapeutic agent for obesity or the like. |