http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1910374-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1cfe242f0f35430601ac180fd3792aed |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2006-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9b541f09ea302307da5ae70edd349d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a664d4ab985c69517414f9946475518d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5c6fcc750897f4b95fdb48fedae8ea6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a010880b7b9bfcfe665957e51fb3636d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e006429d6f1e4843807e72445d78051c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aab614f077cab984b3fc39b3e47416c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a0cf0342093abbb20239e825bb5b704 |
| publicationDate | 2008-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1910374-A1 |
| titleOfInvention | Azacyclic compounds as inhibitors of sensory neurone specific sodium channels |
| abstract | Compounds of the formula (I), and pharmaceutically acceptable salts thereof, are found to be antagonists of SNS sodium channels. They are therefore useful as analgesic and neuroprotective agents; wherein (1) represents (A), (B) or (C); R1 represents: (a)-L-A or L’-A’ wherein L represents a bond or a C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl moiety, A represents a phenyl, 5-to 10-membered heteroaryl, C3-C6 carbocyclyl or 5-to 10 membered heterocyclyl group, L’ represents a C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl moiety, and A’ represents -Het-A or-X-A wherein Het represents -O-, -S- or NR’, and X represents -CO-, -SO-, SO2-, -CO-O-, CO-S, CONR’, -O-CO-, -S-CO-or NR’-CO-, wherein R’ represents hydrogen or C1-C6 alkyl; (b)-L-A-A’ or -L-A-L-A wherein A’ is as defined above , each A is the same or different and is as defined above and each L is the same or different and is as defined above; (c) -A-Z-A wherein Z is -Het-L’, -X-L’, -L’-Het-or L’-X, wherein Het, L’ and X are as defined above and each A is the same or different and is as defined above; (d) -A-Het-Y or -A-X-Y wherein is [L’-Het]n-L’, [L’-Het]n-L’, -[L’-Het]n-A, -L’-B-L’, -L’-B-A or -A-L-A wherein n is from 1 to 4 and B is -X-, -NR’-CO-NR’, -O-CO-NR’- or -NR’-CO-O, and wherein X and L are as defined above, each A is the same or different and is as defined above, each L’ is the same or different and is as defined above, each R’ is the same or different and is as defined above and each Het is the same or different and is as defined above; or (e) -L-CR(A)(A’) or L-CR(A)(L-A) wherein R is hydrogen or C1-C4 alkyl, A’ is as defined above, each L is the same or different and is as defined above and each A is the same or different and is as defined above; R2 represents -L-A-, L’-A’, -L-A-A’ or L-A-L-A wherein L’ and A’ are as defined above, each L is the same or different and is as defined above and each A is the same or different and is as defined above J represents -NR3-, -O- or a direct bond wherein R3 represent s hydrogen C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl; p is an integer from 1 to 3; q is 1 or 2; and one of E and E’ is -CH2- and the other is a direct bond. |
| priorityDate | 2005-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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