http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1907391-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9b4f16ad70ddfeb0b838c113aaae408a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-34 |
| filingDate | 2005-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bd9a2d92e28f45cda3678582f9e756f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e281536d0b4fc5374dfb2d4e10ab0d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86f298c66882cff926861cd940ead4a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae913d1fe3e4f1d66f0e8401fe017726 |
| publicationDate | 2008-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1907391-A1 |
| titleOfInvention | Novel process for acyclic phosphonate nucleotide analogs |
| abstract | The present invention provides a novel process for the preparation of acyclic phosphonate nucleotide analogs using novel intermediates. Thus, for example, (R)-9-(2-phosphonomethoxypropyl)adenine is reacted with dimethylformamide dimethylacetal to give N4-dimethylaminomethyledino-9-(2-phosphonomethoxy ethyl) adenine, which is then reacted with chloromethyl-2-propyl carbonate in presence of triethylamine to give (R)-N4-Dimethylaminomethyledino-9-(2-phosphono methoxypropyl) adenine disoproxil, followed by deprotection with acetic acid to get tenofovir disoproxil. Tenofovir disoproxil is then treated with fumaric acid to give tenofovir disoproxil fumarate. |
| priorityDate | 2005-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 185.