| abstract |
A composition comprising (a) an opioid agonist in non-retarded form, (b) an opioid agonist in retarded form and encapsulated in an enteric coating, (c) an opioid antagonist in non-retarded form and (d) an opioid antagonist in retarded form and encapsulated in an enteric coating, wherein components (a) and (b), and (c) and (d) may not be present in the same particle. The composition may be used for the manufacture of a medicament for treatment of pain and/or substitution therapy of opioid addiction and/or detoxification of opioids. |