| abstract |
An adenosine A 2A receptor antagonist comprising, as an active ingredient, a thiazole derivative represented by the general formula (I) [wherein R 1 represents a substituted or unsubstituted 5-membered aromatic heterocyclic group containing at least one oxygen atom; R 2 represents a substituted or unsubstituted heterocyclic group, -COR 6 (Wherein R 6 represents a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted aromatic heterocyclic group, or the like), or the like; and R 3 represents the general formula (II), -NHCOR 7 (wherein R 7 represents -NR 8 R 9 , or the like) or the like] or a pharmaceutically acceptable salt thereof, and the like are provided, |