| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9414eb8baa5e3ff1d70c9b21b4cdb1ba |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-22 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C225-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 |
| filingDate |
2006-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4be1b883b321854f10be118a8a07c013
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c875e99451fa79deb3682bab420ed77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9685bb3e0fb1e60882c39665d031aea |
| publicationDate |
2008-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1893633-A2 |
| titleOfInvention |
Angiotensin i - converting enzyme (ace) inhibitors |
| abstract |
This invention relates to a process for the synthesis of ketomethylene derivatives of the tripeptide Phe-Gly-Pro ('keto-ACE', compound 5a) and analogues thereof. The synthesis process proceeds via an α,ß-unsaturated keto intermediate. A key feature of the process involves a Horner-Emmons olefination of the , -unsaturated keto-phoshonate with ethyl gyloxylate. Keto-ACE analogues produced by the process of the invention display C-domain selectivity. |
| priorityDate |
2005-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |