abstract |
Non-competitive peptide antagonists of cytokine receptors, methods of their identification and therapeutic uses thereof are disclosed, wherein said peptides are between 7 and 20 ammo acids in length and derived from the extracellular regions of the msulm-like growth factor 1 receptor, human vascular endothelial growth factor receptor, human mterleukm-1 receptor, human mterleukm-4 receptor, human epidermal growth factor receptor or the human growth hormone receptor The compounds disclosed may be used for the treatment of cytokme-associated diseases such as proliferative disorders (colon, breast, prostate and lung cancer), abnormal neovascularization and angiogenesis, age related macular degeneration and proliferative and/or inflammatory skin disorders such as psoriasis |