| abstract |
The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: na) It specifically binds to human platelet membrane glycoprotein VI (GPVI); nb) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and nc) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet. |