| abstract |
[Problem] n To provide a preventive or a remedy for various diarrheas caused by inflammatory colitis, irritable bowel syndrome and other factors. n [Means for Solution] n It was found for the first time that CRAC/SOC channels play a physiologically important role in water secretion or absorption in gastrointestinal epithelia cells and a CRAC/SOC channel inhibitor is useful for preventing and treating diarrhea caused by various factors, and a preventive and a remedy for diarrhea comprising a compound inhibiting the calcium-release-activated calcium channels as an active ingredient, particular a remedy for diarrheal symptoms associated with inflammatory bowel diseases and a remedy for irritable bowel syndrome are provided. |