| abstract |
The invention relates to triazine derivatives of general formula (I) in which R1 represents a heteroaryl group or aryl group; R2 represents a hydrogen atom or a group (C1-C4) alkyl; R3 represents a group -(CH2)n-NR4R5 in which n is equal to 2, 3 or 4 and R4 and R5, independent of one another, represent a (C1-C4) alkyl group or (C3-C7) cycloalkyl, or R4 and R5, together with the nitrogen atom that carries them, form a (C3-C9) heterocycloalkyl group or; R3 represents a group -(CH2)m-NR4R5 in which m is equal to 0, 1, 2, 3 or 4, and; R6 represents a (C3-C9) heterocycloalkyl group comprising at least one nitrogen atom and bound to the triazine nucleus by a carbon atom; R2 and R3, together with the nitrogen atom carrying them, form a (C5-C9) heterocycloalkyl comprising 2 nitrogen atoms; in the form of a base or of an acid addition salt, as well as in the form of a hydrate or solvate. The invention also relates to a method for preparing these triazine derivatives and their use as ligands of α7 nicotinic acetylcholine receptors. |