http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1874311-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6dab731670a1c1ad4743047243d663dd |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4422 |
| filingDate | 2006-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e80af05de188d1f074bf0f3dba1ea022 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8bfd9d5d3701c3f1c6db3363d8fab3c2 |
| publicationDate | 2008-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1874311-A2 |
| titleOfInvention | A method for preventing, delaying or reverting abnormal amyloid deposition |
| abstract | The present invention relates to a method, for preventing, delaying or reverting the progression of pathologies associated with abnormal amyloid deposits, such as that exemplified by Alzheimer's disease. More specifically, the method involves administration of specific molecules pertaining to the dihydropyridine class, such as nicardipine, felodipine, nifedipine, manidipine and niguldipine, objects of the present invention, able to interfere with the formation of amyloidogenic peptides and/or increase their efflux from the central nervous system and, as such, applicable in disease states associated with, or at risk of, cerebral amyloidosis, such as Alzheimer's disease, head trauma(s) , cerebral amyloid angiopathies, spongiform encephalopathies and scrapie. The present invention also relates to methods involving compositions of the molecules, herein claimed, in association with other pharmacologically active substances capable of affecting amyloid burden in brain, such as anti- oxidants, anti- inflammatory agents, protease inhibitors, acetylcholine esterase inhibitors, etc. |
| priorityDate | 2005-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 186.