| abstract |
The invention provides a pharmaceutical composition comprising N-[(1- n butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide (SB 207266) or a pharmaceutically acceptable salt thereof in combination with one or more pharmaceutically acceptable carriers, nwherein at least some of the SB 207266 or the salt thereof is in granulated form, and wherein the SB 207266 or the salt thereof is present in the composition in at least 4 weight % by weight of the composition, nwherein the pharmaceutical composition has been made by a method comprising forming at least some of the SB 207266 or the salt thereof into granules in the presence of a granulating solvent (i.e. using a "wet granulation" process), nand wherein the composition includes an excipient which acts as a granulation aid, and wherein the granulation aid is present inside the granules and is present in at least 15 weight % of the composition. n The granulation aid is preferably microcrystalline cellulose. The granulating solvent can comprise or be water and/or ethanol. n A method of making the pharmaceutical composition is also provided. |