| abstract |
The present invention is directed to a processes for the synthesis of trans isomer of 4,6-disubstituted-tetrahydro-furo, thieno, pyrrolo and cyclopenta-[3,4][l ,3]dioxoles (Formula I). The process comprises the steps of: (a) obtaining a compound of Formula (II), which is a mixture of cis and trans-diastereomers, and (b) chemically decomposing the compound of Formula (II) in a solution comprising a solvent and an acid that is a hydrogen donor or an electron pair acceptor, whereby the cis diastereomer is decomposed and the compound of Formula (I) is obtained. The compounds prepared by the present invention are useful in treating diseases or conditions associated with platelet aggregation and/or platelet activation. |