| abstract |
The invention concerns compounds of formula I, wherein: R represents H, a halogen, an alkyl, a hydroxy, an alkoxy, a -COOR6, -NR4R5, -NH-SO2-AIk, -NH-CO-AIk, -NR6-CO2-AIk, -0-AIk-COOR6, -0-AIk-NR4R5, -0-(CH2)n-Ph, -CO-NR4R5 or -CO-NH-CH(R7)-(CH2)m-COOR6 radical; R1 represents H, a halogen, a cyano a -COOR6, -NR4R5, -NH-SO2-AIk, -NH-CO-CF3, -NH-CO-Ph, -NH-CO-AIk, -NH-CO2-AIk, -CONR4R5 radical, an optionally substituted phenyl or an optionally substituted heteroaryl; R2 and R3 independently of each other represent a hydroxy, an alkoxy, a -COOR6, a nitro, -NR4R5, -NH-CO-AIk, -NH-CO-Ph, -NH-CO2-Alk, -NH-SO2-alk, -CO-NR4R5 or -CO-NHOH; or R2 and R3 form together, with the carbon atoms of the phenyl ring to which they are bound a 6-membered carbon-containing ring, comprising a nitrogen atom and another heteroatom such as oxygen; in base or salt form, as well as in hydrate or solvate form. The invention also concerns a method for preparing said compounds, pharmaceutical composition containing same and the therapeutic uses thereof. |