abstract |
A multi-layered combined rapid and controlled release solid pharmaceutical formulation comprising: nat least one controlled release first layer comprising a physical mixture of a first therapeutic agent, a release rate modifier and a sulfoalkyl ether cyclodextrin for releasing said first therapeutic agent at a controlled rate into a first environment of use; and nat least one rapid release second layer comprising a physical mixture of a second therapeutic agent and a sulfoalkyl ether cyclodextrin for releasing said second therapeutic agent rapidly into a second environment of use; nwherein, nsaid first and second layers are juxtaposed; and nmajor portions of each of said first and second therapeutic agents are not complexed with said sulfoalkyl ether cyclodextrin. |