http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1856073-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b070d762ee824c320f719e5666f35ee8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D281-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D281-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-18 |
| filingDate | 2005-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5088f4f8016ef4bcb952955f5f8bc742 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a77eff94ef6092f07bb05fad1dd04e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b30a4688379c9d135cce2b855e3814d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d5e74ad4672a8f18ae19feec8e0f065 |
| publicationDate | 2010-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1856073-B1 |
| titleOfInvention | A PROCESS FOR THE PREPARATION OF AN 11-(4-SUBSTITUTED-I-PIPERAZINYL)DIBENZO[b,f][1,4]THIAZEPINE DERIVATIVE |
| abstract | A process for the preparation of an 11-(4-substituted-1-piperazinyl)dibenzo[b,f][1,4]thiazepine derivative, of general Formula (I), where A is hydrogen or a -(CH2)2-OH group or a -(CH2)2-0-(CH2)2-OH group, or of a salt thereof, comprises a step in which 10H-dibenzo[b,f][1,4]thiazepin-11-one is reacted with a piperazine derivative in the presence of a titanium alkoxide of general formula Ti(OR)4, where R is a straight or branched alkyl group, having from one to eight carbon atoms to obtain said Formula I derivative or a salt thereof. Where A is -(CH2)2-0-(CH2)2-OH, then the piperazine derivative is 1-(2-(2-hydroxyethoxy)ethyl)piperazine and the 11-(4-substituted-1-piperazinyl)dibenzo[b,f][1,4]thiazepine is quetiapine, (11-(4-(2-(2-hydroxyethoxy)ethyl)-1-piperazinyl)dibenzo[b,f][1,4]thiazepine). The process may comprise an additional step of reacting the quetiapine with fumaric acid to obtain quetiapine hemifumarate. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104803947-A |
| priorityDate | 2005-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 108.