http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1851228-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4643569e4a1e527275b6d9241f614ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1cfe242f0f35430601ac180fd3792aed http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_81c150af8961fd5ae4f74c3565019f3d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 |
| filingDate | 2006-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8070723f3f6982c4f2367e6a6f1ac573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b58b6cd04f1c10eb28123ee65df2b6f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e4121d866b91669764e65ad024e9373 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_105c961b35ba11fb562bf456830b0e8c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3df162b93d6f5c4babe8bc951a263c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07447748823ae1c98c1394ad56292e7f |
| publicationDate | 2007-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1851228-A1 |
| titleOfInvention | Pyrimidothiophene compounds having hsp90 inhibitory activity |
| abstract | Compounds of formula (I) are HSP90 inhibitors, of utility in the treatment of, for example, cancers: wherein R1is -(Alk1)p-(Z)r(Alk2)s-Q wherein AIk1 and AIk2 are optionally substituted divalent C1C3 alkylene or C2-C3 alkenylene radicals, p, r and s are independently 0 or 1 , Z is -O-, -S-, -(C=O)-, -(C=S)-, -SO2-, -C(=O)O-, -C(=O)NRA, -C(=S)NRA-, -SO2NRA-NRAC(=O)-, -NRASO2- or -NRA- wherein RA is hydrogen or C1-C6 alkyl, and Q is hydrogen or an optionally substituted carbocyclic or heterocyclic radical; R2 is optionally substituted aryl or heteroaryl; R3 is hydrogen, an optional substituent, or an optionally substituted (C1-C-6)alkyl, aryl or heteroaryl radical; and R4 is (i) a carboxylic ester, carboxamide or sulfonamide group, or (ii) a -CN group, or (iii) an optionally substituted C1-C6alkyl, aryl, heteroaryl, aryl(C1-C6alkyl)-, or heteroaryl(C1-C6alkyl)- group, or (iv) a group of formula -C(=O)R5 wherein R5 is hydroxyl, optionally substituted C1-C6alkyl, C1-C6alkyoxy, aryl, aryloxy, heteroaryl, heteroaryloxy, aryl(C1-C6alkyl)-, aryl(C1-C6alkoxy)-, heteroaryl(C1 -C6alkyl)-, or heteroaryl(C1-C-6alkoxy)-, or (v) a group of formula -C(=O)NHR6 wherein R6 is primary, secondary, tertiary or cyclic amino, or hydroxyl, optionally substituted C1-C6alkyl, C1-C6alkyoxy, aryl, aryloxy, heteroaryl, heteroaryloxy, aryl(C1-C6alkyl)-, aryl(C1-C6alkoxy)-, heteroaryl(C1-C6alkyl)-, or heteroaryKC1-C6aikoxy)-. |
| priorityDate | 2005-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 464.