http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1849877-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e6e4a54a61ccf2f9cb4d46d5160eafe6 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-16 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6881 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2006-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf662e3bcbc068f4e424b55ac3d44f9a |
| publicationDate | 2007-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1849877-A1 |
| titleOfInvention | Replicative history of T-and B-cell subsets |
| abstract | The invention relates to the field of immunology and immunodiagnostics. More specifically, the invention relates to a method for determining the replicative history of specific subsets of T lymphocytes or B lymphocytes. A method of the invention is among others advantageously used to assess expansion of normal or diseased T-cells or B-cells. Provided is a method for determining the replicative history of a T-cell subset or a B-cell subset, comprising detecting a signal joint nucleotide sequence on a TREC or on a BREC in at least one T-cell or one B-cell of said subset; and detecting a coding joint nucleotide sequence that is formed upon deletion of said TREC or BREC from a chromosome during a TCR or Ig rearrangement in said T-cell or said B-cell, wherein said TCR or Ig gene rearrangement is the last TCR or Ig gene rearrangement before a functional TCR or Ig molecule is formed and wherein the chromosomal coding joint nucleotide sequence is stably retained in the chromosome and preferably involved in the expressed TCR or Ig molecule. Also provided are oligonucleotides and control cells for use in a method of the invention and diagnostic kits comprising oligonucleotides and/or control cells. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2587540-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8346485-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9487830-B2 |
| priorityDate | 2006-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.