| abstract |
Topical exposure of nitric oxide gas to wounds may promote healing of the wound and prepare the wound bed for further treatment and recovery. Nitric oxide gas may be used, to reduce the microbial infection, manage exudate secretion, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide may be provided to induce collagen expression aiding in the closure of the wound. |