http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1845991-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0efa077d881a96aeb1e29b21ef1bbb58 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 |
| filingDate | 2006-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d00f8134a2b38c1e57a9e3e219e1693 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fc54b101da478a5073bc1f8a6b37967 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fc3c37f6ba3bd4d0c6ce8df28fcd726 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b30702b7decccf541fb6305310036770 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8efee4ebbb7b074575edce800cf57a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e37e2d548fdd2a9bda3b1d9335bd1fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fcfce8728f0acb7103938864ed3f7ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_554697ecf08d564d251fa7ff2221595a |
| publicationDate | 2007-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1845991-A2 |
| titleOfInvention | Substituted 5-phenyl pyrimidines i in therapy |
| abstract | The present invention relates to substituted 5-phenyl pyrimidines I, which carry a radical X in the 4-position of the pyrimidine ring, a radical Y in the 6-position of the pyrimidine ring, the radical X denoting a group of the formula NR1R2, OR1a or SR1a, in which R1, R2, independently of each other, denote hydrogen, C1-C10-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C10-haloalkyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing 1, 2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which radicals may be unsubstituted or may carry 1, 2, 3 or 4 radicals Ra1; or the radical NR1R2 may also form a 5- or 6-membered optionally substituted heterocyclic ring, containing 1, 2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which are non-adjacent to the nitrogen of NR1R2, in which two adjacent C atoms or one N atom and one adjacent C atom can be linked by a C1-C4-alkylene chain and wherein the heterocyclic ring may be unsubstituted or may carry 1, 2, 3 or 4 radicals Ra1 as defined in claim 1, R1a has one of the meanings given for R1 except for hydrogen; the radical Y being selected from the group consisting of halogen, cyano, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C3-C6-cycloalkyl, C1-C4-alkoxy, C3-C4-alkenyloxy, C3-C4-alkynyloxy, C1-C6-alkylthio, di-(C1-C6-alkyl)amino or C1-C6-alkylamino, where the alkyl, alkenyl and alkynyl radicals of Y may be substituted by halogen, cyano, nitro, C1-C2-alkoxy or C1-C4-alkoxycarbonyl; and wherein the pyrimidine radical may also carry a radical different from hydrogen in the 2-position and wherein the phenyl ring in the 5-position of the pyrimidine ring may be unsubstituted or carry 1, 2, 3, 4 or 5 radicals L which are different from hydrogen, and the pharmaceutically acceptable salts substituted 5-phenyl pyrimidines for use in therapy, in particular in therapy or treatment of cancerous diseases. |
| priorityDate | 2005-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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