| abstract |
Disclosed is a compound represented by the following general formula (1) : Ar-CO-AA 1 -AA 2 -AA 3 -AA 4 -NH-X-NR 1 R 2 (1) (wherein Ar represents an optionally substituted phenyl group or an aromatic heterocyclic group; AA 1 represents a hydrophobic amino acid; AA 2 represents an unsubstituted amino acid containing 2 or more carbon atoms; AA 3 represents an unsubstituted amino acid containing 2 or more carbon atoms; AA 4 represents a hydrophobic amino acid; X represents a divalent saturated aliphatic hydrocarbon group having 2-6 carbon atoms; and R 1 and R 2 may be the same or different and independently represent a saturated or unsubstituted aliphatic hydrocarbon group having 1-8 carbon atoms, or alternatively R 1 and R 2 may form a ring together with an adjacent nitrogen atom), a salt thereof, or a solvate of them. Also disclosed is a pharmaceutical composition for prevention/treatment of diseases associated with PAR-2 which is composed of the compound represented by the above general formula (1), a salt thereof or a solvate of them and a pharmaceutically acceptable carrier. |