http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1841887-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_132aa5ddba376cda52c2bedb26765245 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-112 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-72 |
| filingDate | 2006-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_607e32317c5f704b660f82b046890914 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2349da8f14d02fcabbf0069090470572 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4545066147710f48fc5cfc9d035fe34 |
| publicationDate | 2007-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1841887-A2 |
| titleOfInvention | Cx3cr1 as a marker which correlates with both disease and disease activity in multiple sclerosis patients |
| abstract | Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by an enormous variability in its clinical presentation and course, in which clear diagnostic parameters are lacking. Here, the inventors performed an RNA screen, which indicated a role for the chemokine receptor CX3CRl as diagnostic marker. Gene expression and flow cytometric analyses demonstrated a significantly lower expression of CX3CRl in MS patients compared to healthy individuals. Importantly, the inventors also found a correlation between disease activity and frequency of CX3CRl+ NK cells. These findings emphasise the involvement of NK cells in the development and course of MS and provide evidence for CX3CRl expression to be a marker for MS patients and disease activity. |
| priorityDate | 2005-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 140.