abstract |
A multi-lamellar tissue-adhesive sheet has a first layer comprising a film-forming polymer, to which first layer is bonded a second layer of material containing tissue-reactive functional groups. The film-forming polymer is preferably a basic polysaccharide, particularly chitosan or a derivative thereof. The tissue-reactive functional groups are preferably NHS ester groups. The sheet is useful for joining a tissue surface to another tissue, or for sealing a tissue surface. |