| abstract |
Disclosed are a cholanic acid-chitosan complex forming self-aggregates and a preparation method thereof, and more particularly, a cholanic acid-chitosan complex which is composed of hydrophobic cholanic acid and hydrophilic chitosan and forms self-aggregates in an aquatic environment, and a method of preparing the cholanic acid- chitosan complex. The cholanic acid-chitosan complex forms self -aggregates, which prolong the drug release period, enhance the selectivity of the complex for tumor tissue, and greatly increase drug loading content when a drug is incorporated into the self -aggregates, compared to chemical bonding, which limits drug incorporation. Thus, the cholanic acid-chitosan complex is useful for anticancer chemotherapy. |