| abstract |
The present invention provides a method of reducing a mammal's immunostimulatory response to a composition comprising the step of administering said composition wherein said composition comprises at least one plasmid, and at least one cationic amphiphile, wherein said at least one plasmid is a CpG altered plasmid and the method of altering said plasmid is chosen from removing at least one CpG motif from said plasmid, mehtylating at least one CpG motif of said plasmid, or removing at least one CpG motif and methylating at least one CpG motif. |