| abstract |
The invention discloses isoxazole derivatives represented by a formula,n nin which nR 1 stands for hydrogen, lower alkyl, amino, halogen, lower alkoxy and the like, nR 2 stands for substituted or unsubstituted aryl and the like, nR 3 stands for hydrogen or lower alkyl, nR 4 stands for substituted or unsubstituted phenyl and the like, and nY stands for -CH 2 , -CO-, -CH(CH 3 )-, -O-, -NH- and the like, or pharmaceutically acceptable salts thereof, which have excellent p38MAPkinase inhibitory action. |