http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1831192-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dd7c27b9ec61781656e6f039702fd568 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_73d50d27d71f6967d024b63c8eba959f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-70 |
| filingDate | 2005-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5135addc3c5533150e1a3669e238d957 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b96ce581e7d442286c6fc21874e9b2ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_caacf81d95e01a17eaf45721562d6f1c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb5c3f5461c2101a9af96ec63303d720 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0af331ffdabae0d174d47ff8061b68c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15ed23f1df287de39d44ca8a6a6f981c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bcdbc64fb4f25acc31105d97dbdb4f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79763321a70421a670fc7b5670ec6f4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d53f44e22bd5e490635e02592b6eb83 |
| publicationDate | 2011-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1831192-B1 |
| titleOfInvention | Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same |
| abstract | The present invention is related to benzothiophen-2-carbonylguanidine derivatives, a preparation method thereof, and pharmaceutical compositions containing the same. The derivatives have potent inhibitory effect on the sodium/hydrogen exchanger NHE-I, improve the functional recovery of ischemia/reperfusion-induced heart injury in isolated ischemic heart models, and significantly reduce the myocardiac infarct size in in vivo ischemic animal models, thereby showing excellent cardioprotective effects. Also, the derivatives are protective of both neuronal cells and the brain as proven by their protective effects on neuronal cells from necrosis and apoptosis and by their ability to significantly reduce cerebral infarct sizes in in vivo ischemic brain models. The derivatives can be effectively used for the prevention and treatment of ischemic heart diseases such as myocardiac infarction, arrhythmia, angina pectoris and the like, and cerebrovascular diseases such as cerebral stroke and be used as cardioprotective agents to the patients undergoing reperfusion therapy including chemicals such as thrombolytic agents, or surgery such as coronary artery bypass and percutaneous transluminal coronary angioplasty. |
| priorityDate | 2004-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 290.