abstract |
A novel compound represented by the following formula (1) or a salt thereof [wherein R 1 , R 5 , R 6 , R 7 , and R 8 represent hydrogen atom, a halogen atom, hydroxyl group, an alkyl group, an alkenyl group and the like; X 1 ···X 2 represents -CH(R 2 )-CH(R 3 ) - , -CH(R 2 )-CH(R 3 )-CH(R 4 )-, -C(R 2 )=C(R 3 )-, or -C(R 2 )=C(R 3 )-CH(R 4 )- (R 2 , R 3 , and R 4 represent hydrogen atom, or an alkyl group); A 1 , A 11 , A 2 , and A 21 represent hydrogen atom, or an alkyl group; Y represents -CH(A 3 )-, -CH(A 3 )-C(A 4 )(A 41 )-, -CH(A 3 )-C(A 4 )(A 41 )-C(A 5 )(A 51 )-, or a single bond (A 3 , A 4 , A 41 , A 5 , and A 51 represent hydrogen atom, or an alkyl group), and Z represents hydroxyl group, or -N(A 6 )(A 61 ) (As represents hydrogen atom, or an alkyl group, and A 61 represents hydrogen atom, an alkyl group, a substituted alkyl group and the like)], having an action of potently inhibiting phosphorylation of myosin regulatory light chain. |