Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-86 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-747 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-755 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-61 |
filingDate |
2005-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16cefeb7026b0320d448bde79be880eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a4f5bd2a2e49a425256d298a762d7ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ef60db07a3944bb0dd0f5dbf713cbb4 |
publicationDate |
2007-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-1819656-A2 |
titleOfInvention |
Synthesis of 1,5-distributed-2-hydroxy-gibbatetraen-6-ones |
abstract |
1,5-disubstituted-2-hydroxy-gibbatetraen-6-ones are useful as estrogen receptor modulators and as precursors to estrogen receptor modulators. The current invention provides a method for the synthesis of 1,5-disubstituted-2-hydroxy-gibbatetraen-6-ones from simple indanone starting materials via a Robinson-type annulation followed by an internal alkylation reaction. This invention further describes the novel use of a fluoroethyl substituent as a latent alkylating group for an internal cyclization reaction. |
priorityDate |
2004-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |