| abstract |
A compound with p38MAP kinase inhibiting activity useful as a pharmaceutical, represented by the general formula: (I) [wherein all the characters are as defined in the description], or its salt, N-oxide or solvate, or a prodrug thereof. Further, there are provided a process for producing the same and usage thereof. The compound of the general formula (I) has a p38MAP kinase inhibiting activity and is useful for the prevention and/or treatment of diseases in which an abnormal production of cytokine, such as inflammatory cytokine or chemokine, or an over-reaction thereto would be instrumental in the cause and aggravation of pathologic condition thereof, namely, cytokine-mediated diseases, for example, inflammatory diseases, respiratory diseases, circulatory diseases, central nervous system diseases, etc. |