http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1806348-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05ff905fdc49089f5f25746eaeb40190 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 1998-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4ba124fc6b78805e16635c16aee02df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7555a270ed55d5455f9c93ca522f1c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78d760643a8fc54df7dcb373090e13cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0f9968fc0b4220821ea06a7e6d7dfa4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04cf503227aef7d3599d1cdaea3e9f7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f000dec13856a43b42397703c0b45d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f42350c72c43d886e98c714600611fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a0839385e1ba29a0067d0eac8b0da48 |
| publicationDate | 2007-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1806348-A2 |
| titleOfInvention | Pyrido (2,3-D)Pyrimidines as inhibitors of cellular proliferation |
| abstract | This invention provides pyridopyrimidines and 4-aminopyrimidines that are useful for treating cell proliferatives disorders, such as cancer and restenosis. We have now discovered a group of 7,8-dihydro-2-(amino and thio)pyrido[2,3-d]pyrimidincs and 2,4-diaminopyrimidines that are potent inhibors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases. The compounds are readily synthesized and can be administered by a variety of routes, including orally, and have sufficient bioavailability. This invention provides compounds of Formula (I) and Formula (II) where W is NH, S, SO or SO 2 , R 1 includes phenyl and substituted phenyl, R 2 includes alkyl and cycloalkyl, R 3 includes alkyl and hydrogen, R 8 and R 9 include hydrogen and alkyl, and Z is carboxy. This invention also provides pharmaceutical formulations comprising a compound of Formula (I and II) together with a pharmaceutically acceptable carrier, diluent, or excipient therefor. |
| priorityDate | 1997-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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