| abstract |
It is intended to provide a drug for preventing, ameliorating or treating vascular restenosis, ischemic diseases, allergic diseases, inflammatory diseases, autoimmune diseases, cancer metastasis or infiltration (cancerous metastasis/infiltration) or cachexia based on the inhibition of a plural number of transcriptional regulators. Namely, a chimeric (double) decoy (a decoy molecule) having a plural number of transcriptional regulator-binding sequences per molecule. Thus, it can inhibit a plural number of transcriptional regulator-inhibiting activities by a single molecule. For example, stenosis in an inosculation site of an artificial vessel is resulted from thickening in the vascular endosporium mainly caused by activated cell proliferation due to an inflammatory reaction in the inosculation site. By simultaneously inhibiting two transcriptional regulators participating in the inflammation and the cell proliferation with the use of the above-described chimeric decoy, therefore, the thickening in the vascular wall can be inhibited. |