| abstract |
Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula (I) wherein R1, R2, and R3 are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and use for treating cognition impairment memory impairment, psychosis, schizophrenia, depression, allergic or inflammatory disease, chronic obstructive pulmonary disease, neurodegeneration, stroke, Alzheimer’s disease, multiple sclerosis. |