| titleOfInvention |
Solid pharmaceutical composition comprising the thiazolyl methyl ester of [5s-(5r*,8r*,10r*,11r*)]-10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-1(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-2,4,7,12-tetraazatridecan-13-oic acid and preparation method thereof |
| abstract |
The invention relates to a solid pharmaceutical composition comprising the thiazolyl methyl ester of [5S-(5R*,8R*,10R*,11R*)]-10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-1(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-2,4,7,12-tetraazatridecan-13-oic acid and to a compound that enables gastrointestinal fluid to penetrate to penetrate said composition, which is selected from the group containing silicates and silica oxide. The invention also relates to a method of preparing said composition, comprising a mixing step in which the solvent aggregation time and speed are strictly controlled. |