| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-567
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2833
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-467
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-468 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-567 |
| filingDate |
2005-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f59367f9f59ce3c9ea9a7040523702a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54670bd1484a188c539d875b769c5210 |
| publicationDate |
2007-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1789087-A2 |
| titleOfInvention |
Engineered antibody fragment that irreversibly binds an antigen |
| abstract |
The present invention provides mutant antibodies with infinite affinity for a target antigen. The antibodies comprise a mutant amino acid at a position within or proximate to a complimentarity determining region of the antibody and a linker covalently bound to the mutant amino acid, the linker comprising a reactive functional group. Subsequent to binding an antigen, the reactive functional group is converted to a covalent bond by reaction with a group of complementary reactivity on the bound antigen. The invention also provides bispecific antibodies with infinite binding affinity that comprise a second domain that specifically binds a metal chelate. The invention further provides methods of using such antibodies to diagnose and treat diseases and conditions. |
| priorityDate |
2004-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |